POSTER NO: 85

The Relationship of Synaptonemal Complex and Male Infertility in Human

¹Jingyu Liu, ²Xianlu Zeng, ²Chuanshan Zhang
¹Department of Biology, Henan University, KaiFeng, 475001, ²institute of Genetics and Cytology, Northeast Normal University, Changchun, 130024

It was said that infertility affected nearly 11% of all men. A genetic origin of male infertility is assumed in a significant number of men in which anatomical, environmental and endocrinological data do not explain this infertility. The genetic origins of male infertility may be classified in three main groups: chromosome abnormalities, microdeletions and gene mutations. A growing literature shows spermatogenesis failure or reproductive failure (pregnancy wastages) has occurred in male carriers of chromosomal distortion/aberration. But the mechanisms remain largely unsolved. SC of human spermatocytes from such carrier offers new information for the relationship of them. This review aims to summarize recent development of SC application on male infertile diagnosis and sum up our recent studying results. The relationship of mechanisms of male infertility/sterility and SC were discussed and reviewed: 1. The association of XY-bivalent and the rearranged autosomes can inference or effect, by their contact, X chromosome normal functions. 2. This heterosynapsis, by taking place early, in rearranged autosomes resulted in unbalanced germs and pregnancy wastages. 3. Male infertility is related to the incomplete pairing in regions of rearranged autosomes breaks. 4. SC fragment, LE swelling and pairing disorder resulted in spermatogenic failure. 5. Yq chromosome microdeletions or gene mutations resulted in spermatogenesis failure.